Postpartum depression (PPD) is a serious health issue that can affect about 15% of the
female population within after giving birth. It often conveys significant negative …

Highlights•Perinatal depression is a common complication of pregnancy.•It is widely
overlooked partly due to lack of biomarkers.•BDNF has psychostablizing effects with …

BackgroundRace, psychiatric history, and adverse life events have all been independently
associated with postpartum depression (PPD). However, the role these play together in …

Obesity, affecting one in three pregnant women worldwide, is not only a major obstetric risk
factor. The resulting low‐grade inflammation may have a long‐term impact on the offspring's …

Postpartum depression (PPD) is a severe psychiatric disorder with devastating
consequences on child development and mother's health. Dysregulation of glutamatergic …

Background Postpartum depression (PPD) is the most frequent psychiatric complication
during the postnatal period and its mechanisms are not fully understood. Metabolomics, can …

Abstract Allopregnanolone (3α, 5α-tetrahydroprogesterone; pharmaceutical formulation:
brexanolone) is a neurosteroid that has recently been approved for the treatment of …

Introduction Compared to women who have given birth before (ie, multiparas), those giving
birth for the first time (ie, primiparas) show higher cortisol levels. Psychological factors may …

Studies in the 1980s revealed endogenous metabolites of progesterone and
deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the …

Major depressive disorder is a very common serious mental illness with increasing
prevalence in the population. Its pathology includes biochemical, morphological, and …