Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
Use cases for genetic epidemiology in malaria elimination
R Dalmat, B Naughton, TS Kwan-Gett, J Slyker… - Malaria journal, 2019 - Springer
Background While traditional epidemiological approaches have supported significant
reductions in malaria incidence across many countries, higher resolution information about …
reductions in malaria incidence across many countries, higher resolution information about …
[HTML][HTML] An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
A Ahouidi, M Ali, J Almagro-Garcia… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …
populations to evolve in response to malaria control interventions. The widespread use of …
Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies
W Tavares, J Morais, JF Martins, RJ Scalsky… - Malaria Journal, 2022 - Springer
Over the past two decades, a considerable expansion of malaria interventions has occurred
at the national level in Angola, together with cross-border initiatives and regional efforts in …
at the national level in Angola, together with cross-border initiatives and regional efforts in …
A population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivax
V Rougeron, L Boundenga, C Arnathau… - FEMS Microbiology …, 2022 - academic.oup.com
Malaria is considered one of the most important scourges that humanity has faced during its
history, being responsible every year for numerous deaths worldwide. The disease is …
history, being responsible every year for numerous deaths worldwide. The disease is …
Performance of SNP barcodes to determine genetic diversity and population structure of Plasmodium falciparum in Africa
Panels of informative biallelic single nucleotide polymorphisms (SNPs) have been proposed
to be an economical method to fast-track the population genetic analysis of Plasmodium …
to be an economical method to fast-track the population genetic analysis of Plasmodium …
Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia
Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia in
2008 and 2014 were analysed to identify changes possibly related to the scale-up of …
2008 and 2014 were analysed to identify changes possibly related to the scale-up of …
Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development
CW Duffy, A Amambua-Ngwa, AD Ahouidi, M Diakite… - Scientific Reports, 2018 - nature.com
Parasites infect hosts in widely varying environments, encountering diverse challenges for
adaptation. To identify malaria parasite genes under locally divergent selection across a …
adaptation. To identify malaria parasite genes under locally divergent selection across a …
High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya
Novel interventions that leverage the heterogeneity of parasite transmission are needed to
achieve malaria elimination. To better understand spatial and temporal dynamics of …
achieve malaria elimination. To better understand spatial and temporal dynamics of …