[HTML][HTML] Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure
Z Zhang, Z Yang, S Wang, X Wang, J Mao - Biomedicine & …, 2024 - Elsevier
The pyroptosis of cardiomyocytes has become an essential topic in heart failure research.
The abnormal accumulation of these biological factors, including angiotensin II, advanced …
The abnormal accumulation of these biological factors, including angiotensin II, advanced …
Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release
Gasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release
and downstream immune responses upon inflammasome activation, which play important …
and downstream immune responses upon inflammasome activation, which play important …
From fat to fire: The lipid–inflammasome connection
PK Anand - Immunological Reviews, 2024 - Wiley Online Library
Inflammasomes are multiprotein complexes that play a crucial role in regulating immune
responses by governing the activation of Caspase‐1, the secretion of pro‐inflammatory …
responses by governing the activation of Caspase‐1, the secretion of pro‐inflammatory …
Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation
S Leishman, NM Aljadeed, L Qian, S Cockcroft… - Cell Reports, 2024 - cell.com
Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains
elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 …
elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 …
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity
Gasdermin-mediated inflammatory cell death (pyroptosis) can activate protective immunity in
immunologically cold tumors. Here, we performed a high-throughput screen for compounds …
immunologically cold tumors. Here, we performed a high-throughput screen for compounds …
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation
L Nie, C Fei, Y Fan, F Dang, Z Zhao, T Zhu, X Wu, T Dai… - Molecular Cell, 2024 - cell.com
NLRP3 inflammasome activation, essential for cytokine secretion and pyroptosis in
response to diverse stimuli, is closely associated with various diseases. Upon stimulation …
response to diverse stimuli, is closely associated with various diseases. Upon stimulation …
Cleavage-independent GSDME activation by UVC
Gasdermins (GSDMs) are mediators of cell death that trigger membrane lysis. A study shows
that full-length GSDME induces pyroptosis after ultraviolet irradiation, involving GSDME …
that full-length GSDME induces pyroptosis after ultraviolet irradiation, involving GSDME …
Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application
LDJ Schiffelers, YM Tesfamariam, LM Jenster… - Nature …, 2024 - nature.com
Inflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-
inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble …
inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble …
Inflammasome-independent pyroptosis
X Liu, J Lieberman - Current Opinion in Immunology, 2024 - Elsevier
Gasdermins are membrane pore–forming proteins that cause pyroptosis, an inflammatory
cell death in which cells burst and release cytokines, chemokines, and other host alarm …
cell death in which cells burst and release cytokines, chemokines, and other host alarm …
Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly
E Margheritis, S Kappelhoff, J Danial, N Gehle… - The EMBO …, 2024 - embopress.org
Gasdermin D (GSDMD) executes the cell death program of pyroptosis by assembling into
oligomers that permeabilize the plasma membrane. Here, by single-molecule imaging, we …
oligomers that permeabilize the plasma membrane. Here, by single-molecule imaging, we …