Psoriasis is a common, chronic and relapsing autoimmune skin disease. Clinical
characteristics of this disease are sharply-demarcated erythematous plaques covered with …

IκB kinase α (IKKα), one of the two catalytic subunits of the IKK complex involved in nuclear
factor κB (NF‐κB) activation, also functions as a molecular switch that controls epidermal …

IKKα is known as an essential protein for skin homeostasis. However, the lack of suitable
models to investigate its functions in the skin has led to IKKα being mistakenly considered as …

Exposure to ultraviolet B (UVB) irradiation from sunlight induces the upregulation of VEGF, a
potent angiogenic factor that is critical for mediating angiogenesis-associated photodamage …

In this study, we demonstrate that the expression in tumorigenic epidermal cells of a
catalytically inactive form of CYLD (CYLD C/S) that mimics the identified mutations of cyld in …

About 5% of all cutaneous squamous cell carcinomas (cSCCs) metastasize, which is the
principal cause of death by this type of cancer. However, to date there are no reliable …

Background/Aims: MicroRNAs (miRNAs) are a group of non-coding RNAs that play diverse
roles in pancreatic carcinogenesis. In pancreatic ductal adenocarcinoma (PDAC), NF-kB is …

Constitutive activation of NF-κB occurs in a significant percentage of human cancers.
Genetic abnormalities of tumors often enhance normal NF-κB signaling. Chronic …

CYLD is a gene mutated in familial cylindromatosis and related diseases, leading to the
development of skin appendages tumors. Although the deubiquitinase CYLD is a skin tumor …

IKKβ is a subunit of the IκB kinase (IKK) complex required for NF-κB activation in response to
pro-inflammatory signals. NF-κB regulates the expression of many genes involved in …