Abstract Purpose of Review Hyperexpression of classical HLA class I (HLA-I) molecules in
insulin-containing islets has become a widely accepted hallmark of type 1 diabetes …

Further investigation of the roles of intestinal microbiome and physical force transduction
toward SpA pathogenesis, strategies to improve delay in SpA diagnosis, biomarkers to …

We propose a peptide binding hypothesis of psoriatic arthritis based on a shared pattern of
negative charge in the 'B'pocket of the HLA-B and HLA-C molecules encoded by the …

Background Chronic renal insufficiency (CRI) is a global public health problem with a high
incidence in the Romanian population. In this study, we aimed to investigate genomic HLA …

Simple Summary Tumor immunogenicity is one of the main factors influencing responses to
cancer therapies and long-lasting antitumoral immunity. In this review, we will cover how …

Background: Solid organ transplantation is a life-saving medical operation that has
progressed greatly because of developments in diagnostic tools and histocompatibility tests …

This review is a simple guide to the deeper meaning of the association of a disease with a
particular HLA allele. We will first review some principles of the function of the adaptive …

Colorectal cancer is a common cancer in both genders, and 50% develop metastases which
is the dominating cause of death from CRC, most frequently located in the liver (CLM). Only …

Increasing our knowledge of the HLA system, including both the complete sequence
description and the assessment of its diversity at the worldwide human population-level, is of …

Human leukocyte antigen (HLA) molecules play an important role in immune responses by
interacting with cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Classical HLA …