Bacterial inclusion bodies are industrially exploitable amyloids

A De Marco, N Ferrer-Miralles… - FEMS microbiology …, 2019 - academic.oup.com
Understanding the structure, functionalities and biology of functional amyloids is an issue of
emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria …

Microbial ageing and longevity

RZ Moger-Reischer, JT Lennon - Nature Reviews Microbiology, 2019 - nature.com
Longevity reflects the ability to maintain homeostatic conditions necessary for life as an
organism ages. A long-lived organism must contend not only with environmental hazards …

[HTML][HTML] Mitochondria dysfunction and impaired response to oxidative stress promotes proteostasis disruption in aged human cells

D Trigo, A Nadais, A Carvalho, B Morgado, F Santos… - Mitochondrion, 2023 - Elsevier
The plastic architecture of the mitochondrial network and its dynamic structure play crucial
roles ensuring that varying energetic demands are rapidly met. Given the brain's high …

[HTML][HTML] Employing bacterial microcompartment technology to engineer a shell-free enzyme-aggregate for enhanced 1, 2-propanediol production in Escherichia coli

MJ Lee, IR Brown, R Juodeikis, S Frank… - Metabolic engineering, 2016 - Elsevier
Bacterial microcompartments (BMCs) enhance the breakdown of metabolites such as 1, 2-
propanediol (1, 2-PD) to propionic acid. The encapsulation of proteins within the BMC is …

[HTML][HTML] A quantitative survey of bacterial persistence in the presence of antibiotics: towards antipersister antimicrobial discovery

JE Salcedo-Sora, DB Kell - Antibiotics, 2020 - mdpi.com
Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …

[HTML][HTML] Senescence in bacteria and its underlying mechanisms

UK Steiner - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Bacteria have been thought to flee senescence by dividing into two identical daughter cells,
but this notion of immortality has changed over the last two decades. Asymmetry between …

[HTML][HTML] Getting closer to decrypting the phase transitions of bacterial biomolecules

K Sołtys, A Tarczewska, D Bystranowska, N Sozańska - Biomolecules, 2022 - mdpi.com
Liquid–liquid phase separation (LLPS) of biomolecules has emerged as a new paradigm in
cell biology, and the process is one proposed mechanism for the formation of membraneless …

Design and Reconstruction of Regulatory Parts for Fast-Growing Vibrio natriegens Synthetic Biology

F Wu, W Chen, Y Peng, R Tu, Y Lin, J Xing… - ACS Synthetic …, 2020 - ACS Publications
The fast-growing Vibrio natriegens is an attractive robust chassis for diverse synthetic
biology applications. However, V. natriegens lacks the suitable constitutive regulatory parts …

[HTML][HTML] Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates

K Phadwal, D Kurian, MKF Salamat, VE MacRae… - Scientific reports, 2018 - nature.com
Autolysosomal dysfunction and unstable microtubules are hallmarks of chronic
neurodegenerative diseases associated with misfolded proteins. Investigation of impaired …

Aging and immortality in unicellular species

M Florea - Mechanisms of ageing and development, 2017 - Elsevier
It has been historically thought that in conditions that permit growth, most unicellular species
do not to age. This was particularly thought to be the case for symmetrically dividing species …