Zinc is an essential trace element that is crucial for growth, development, and the
maintenance of immune function. Its influence reaches all organs and cell types …

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

The JAK (Janus kinase) family members serve essential roles as the intracellular signalling
effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine …

Extracellular proteins bound to cell-surface receptors can change nuclear gene expression
patterns in minutes, with far-reaching consequences for development, cell growth and …

Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

Interferons play key roles in mediating antiviral and antigrowth responses and in modulating
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …

The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …