Integral membrane proteins (MPs) are important drug targets across most fields of medicine,
but historically have posed a major challenge for drug discovery due to difficulties in …

This Viewpoint, which accompanies a Special Issue focusing on membrane
mechanosensors, discusses unifying and unique features of both established and emerging …

Solute carrier spinster homolog 2 (SPNS2), one of only four known major facilitator
superfamily (MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) …

Lipids play important roles in regulating membrane protein function, but the molecular
mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a …

Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and
shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of …

While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …

Cholesterol and phosphatidyl inositol 4, 5-bisphosphate (PIP2) are hydrophobic molecules
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …

Abstract Structure determination of membrane proteins has highlighted the many roles
played by lipids in influencing overall protein architecture. It is now widely accepted that …

Membrane proteins exist within the highly hydrophobic membranes surrounding cells and
organelles, playing key roles in cellular function. It is becoming increasingly clear that the …