In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Hydrogen sulfide (H 2 S) has profound biological effects within living organisms and is now
increasingly being considered alongside other gaseous signalling molecules, such as nitric …

Several of the uremic toxins, which are difficult to remove by dialysis, originate from the gut
bacterial metabolism. This opens opportunities for novel targets trying to decrease …

Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing
cognitive disorders and dementia. Stroke is also highly prevalent in this population and is …

Emerging evidence indicates that the dysregulation of cellular redox homeostasis and
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …

Chronic renal failure (CRF) is a major public health problem worldwide. Hydrogen sulfide
(H2S) plays important roles in renal physiological and pathophysiological processes …

Hydrogen sulfide (H2S) is an important biological mediator across all kingdoms of life and
plays intertwined roles in various disciplines, ranging from geochemical cycles to industrial …

Increased levels of homocysteine have been established as a risk factor for cardiovascular
disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is …

Results Baseline characteristics were 391 (61%) male; median age 12 years; median eGFR
54 ml/min per 1.73 m 2; 448 (69%) nonglomerular diagnosis. Over a median follow-up of 4.8 …

In the past, hydrogen sulfide (H2S) was considered as a poisonous gas or waste of the
body. Later, researchers found that H2S-producing enzymes exist in mammals. Moreover …