When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Transplantation is the only curative treatment for patients with kidney failure but it poses
unique immunological challenges that must be overcome to prevent allograft rejection and …

Organ transplantation is a life-saving treatment for patients with end-stage disease, but
survival rates after transplantation vary considerably. There is now increasing evidence that …

Background Genetically engineered pigs could provide a source of kidneys for clinical
transplantation. The two longest kidney graft survivals reported to date have been 136 and …

Early diagnosis of allograft rejection helps to improve the immune‐related management of
transplant recipients. The clinically‐used core needle biopsy method is invasive and subject …

The renin–angiotensin system (RAS) has long been described in the field of cardiovascular
physiology as the main player in blood pressure homeostasis. However, other effects have …

Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Upon solid organ transplantation and during cancer immunotherapy, cellular stress
responses result in the release of damage-associated molecular patterns (DAMPs). The …

Healthy pregnancy is the most successful form of graft tolerance, whereas preterm labor
(PTL) may represent a breakdown in maternal-fetal tolerance. Although maternal immune …

Submicron biomaterials have recently been found with a wide range of applications for
biomedical purposes, mostly due to a considerable decrement in size and an increment in …