Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF-κB/NLRP3/GSDMD signaling pathways
Diclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction
and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug …
and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug …
Downregulation of IL-1β/p38 mitogen activated protein kinase pathway by diacerein protects against kidney ischemia/reperfusion injury in rats
EAE Fathy, SAW Abdel-Gaber, MFG Ibrahim, K Thabet… - Cytokine, 2024 - Elsevier
Renal ischemia–reperfusion (I/R) can be precipitated by multiple clinical situations that lead
to impaired renal function and associated mortality. The resulting tubular cell damage is the …
to impaired renal function and associated mortality. The resulting tubular cell damage is the …
Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model
Objectives We aimed to analyze the effects of diacerein in a rat model of partial unilateral
ureteral obstruction (PUUO). Methods We randomly divided 24 female rats into three groups …
ureteral obstruction (PUUO). Methods We randomly divided 24 female rats into three groups …