The two vascular systems of our body are the blood and lymphatic vasculature. Our
understanding of the cellular and molecular processes controlling the development of the …

Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell
junctions that are crucial for the maintenance of vessel integrity and proper lymphatic …

Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

Gap junctions are intercellular conduits for small molecules made up by protein subunits
called connexins. A large number of connexin genes were found in mouse and man, and …

Lymphatic valves (LVs) are cusped luminal structures that permit the movement of lymph in
only one direction and are therefore critical for proper lymphatic vessel function. Congenital …

Spinal cord injury (SCI) is associated with venous vascular dysfunction below the level of
injury, resulting in dysregulation of tissue fluid homeostasis in afflicted skin. The purpose of …

Background: Lung cancer remains the leading cause of cancer-related death, largely owing
to the lack of effective treatments. A tumour vascular targeting strategy presents an attractive …

Gap junction channels made of different connexins have distinct permeability to second
messengers, which could affect many cell processes, including lens epithelial cell division …

Connexin channels mediate electrical coupling, intercellular molecular signaling, and
extracellular release of signaling molecules. Connexin proteins assemble intracellularly as …

Abstract Connexin43 (CX43), encoded by Gja1 in the mouse, is highly expressed in
decidual cells and is known to be important for the transformation of stromal cells into the …