Modified biotin-binding protein, fusion proteins thereof and applications

R Malley, Y Lu, F Zhang - US Patent 9,499,593, 2016 - Google Patents
The disclosure provides modified biotin-binding proteins which can be expressed in soluble
form in high yield in bacteria. Also provided are fusion proteins comprising the modified …

Protein antigens that provide protection against pneumococcal colonization and/or disease

R Malley, Y Lu, F Zhang - US Patent 11,576,958, 2023 - Google Patents
The present application is generally directed to novel pneumococcal polypeptide antigens
and nucleic acids encoding such antigens, and immunogenic compositions comprising such …

Compositions and methods of enhancing immune responses to flagellated bacterium

W Bottje, B Hargis, L Berghman, YM Kwon… - US Patent …, 2015 - Google Patents
Vaccines comprising fliC and CD 154 polypeptides and Sal monella enteritidis Vaccine
vectors comprising fliC polypep tides are provided. Also provided arc methods of enhancing …

Vaccine vectors and methods of enhancing immune responses

L Berghman, W Bottje, B Hargis, S Layton - US Patent 8,956,618, 2015 - Google Patents
Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1
polypeptide present on the surface of the vaccine vector. Compositions comprising the …

Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use

DA Emery, DE Straub, L Wonderling… - US Patent …, 2014 - Google Patents
US8709436B2 - Polypeptides and immunizing compositions containing gram positive
polypeptides and methods of use - Google Patents US8709436B2 - Polypeptides and …

Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use

DA Emery, DE Straub, L Wonderling… - US Patent …, 2011 - Google Patents
US8007811B2 - Polypeptides and immunizing compositions containing gram positive
polypeptides and methods of use - Google Patents US8007811B2 - Polypeptides and …

Vaccine and methods to reduce campylobacter infection

B Hargis, NR Pumford, YM Kwon, S Layton - US Patent 8,961,990, 2015 - Google Patents
Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for
enhancing the immune response to Campylobacter are provided herein. The vaccine …

Modified biotin-binding protein, fusion proteins thereof and applications

R Malley, Y Lu, F Zhang - US Patent 10,017,548, 2018 - Google Patents
US10017548B2 - Modified biotin-binding protein, fusion proteins thereof and applications -
Google Patents US10017548B2 - Modified biotin-binding protein, fusion proteins thereof and …

Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use

DA Emery, DE Straub, L Wonderling… - US Patent …, 2011 - Google Patents
US8025885B2 - Polypeptides and immunizing compositions containing gram positive
polypeptides and methods of use - Google Patents US8025885B2 - Polypeptides and …

Vaccine vectors and methods of enhancing immune responses

L Berghman, W Bottje, B Hargis, S Layton - US Patent 9,913,893, 2018 - Google Patents
Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1
polypeptide present on the surface of the vaccine vector. Compositions comprising the …