Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors

MB Sokol, NG Yabbarov, MR Mollaeva… - …, 2022 - Taylor & Francis
Background: Serious side effects caused by paclitaxel formulation, containing toxic
solubilizer Cremophor® EL, and its nonspecific accumulation greatly limit clinical paclitaxel …

Synthesis and biological properties of egfr-targeted photosensitizer based on cationic porphyrin

YS Bortnevskaya, NA Shiryaev, NS Zakharov… - Pharmaceutics, 2023 - mdpi.com
Photodynamic therapy (PDT) in oncology is characterized by low invasiveness, minimal side
effects, and little tissue scarring. Increasing the selectivity of PDT agents toward a cellular …

Structural optimization of platinum drugs to improve the drug-loading and antitumor efficacy of PLGA nanoparticles

MB Sokol, MV Chirkina, NG Yabbarov, MR Mollaeva… - Pharmaceutics, 2022 - mdpi.com
Currently, molecular dynamics simulation is being widely applied to predict drug–polymer
interaction, and to optimize drug delivery systems. Our study describes a combination of in …

Carboxylated superparamagnetic Fe3O4 nanoparticles modified with 3-amino propanol and their application in magnetic resonance tumor imaging

C Wang, Y Wang, W Xiao, X Chen, R Li, Z Shen, F Lu - BMC cancer, 2023 - Springer
Background Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are of potential
magnetic resonance imaging (MRI) contrast agents for tumor diagnosis. However, ultrasmall …

Long-lasting exendin-4-loaded PLGA nanoparticles ameliorate cerebral ischemia/reperfusion damage in diabetic rats

CH Chung, SD Chung, YH Cheng, CP Yang… - Journal of Personalized …, 2022 - mdpi.com
Exendin-4 (Ex-4) is an incretin mimetic agent approved for diabetes treatment and neuronal
protection. However, the required frequent injections restrict its clinical application. We …

Synergetic Enhancement of Tumor Double-Targeted MRI Nano-Probe

N Yabbarov, E Nikolskaya, M Sokol… - International Journal of …, 2022 - mdpi.com
The conventional targeted delivery of chemotherapeutic and diagnostic agents utilizing
nanocarriers is a promising approach for cancer theranostics. Unfortunately, this approach …

Biomimetic Materials Based on Poly-3-hydroxybutyrate and Chlorophyll Derivatives

PM Tyubaeva, KG Gasparyan, RR Romanov… - Polymers, 2023 - mdpi.com
Electrospinning of biomimetic materials is of particular interest due to the possibility of
producing flexible layers with highly developed surfaces from a wide range of polymers …

Pharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll α Derivative

MB Sokol, VA Beganovskaya, MR Mollaeva… - Pharmaceutics, 2024 - mdpi.com
In this study, we described physico-chemical properties of novel nanoformulation of
photosensitizer-pyropheophorbide α 17-diethylene glycol ester (XL)(chlorophyll α …

Photophysical properties and aggregation behavior of diethylene glycol substituted pyropheophorbide-a in cationic surfactant solutions

MA Gradova, OV Gradov, AV Lobanov… - Journal of Porphyrins …, 2022 - World Scientific
The aggregation behavior of a novel amphiphilic photosensitizer-pyropheophorbide-a 17-
diethylene glycol ester 1 was studied in aqueous and aqueous-organic mixtures by means …

Mineralization of Shells of Emulsion Polyelectrolyte Microcapsules by Calcium Carbonate

AV Buslenko, TV Bukreeva, AP Chistyakov… - Crystallography …, 2023 - Springer
The calcium-carbonate-induced mineralization of multilayer shells of emulsion capsules,
formed using layer-by-layer assembly of polyelectrolytes, has been investigated. Optimal …