Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for
significant mortality and morbidity worldwide. The genus comprises more than seventy …

Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Sphingolipids are essential components of eukaryotic cells. In this review, we want to
exemplarily illustrate what is known about the interactions of sphingolipids with various …

Ceramide and sphingomyelin (SM) are major components of the double membrane-bound
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …

Lipid rafts are ubiquitous in cells. They are identified as cholesterol and glycosphingolipid
enriched microdomains on cellular membranes. They serve as platforms for cellular …

Flavivirus infection capitalizes on cellular lipid metabolism to remodel the cellular intima,
creating a specialized lipid environment conducive to viral replication, assembly, and …

The Zika virus (ZIKV) is a mosquito-borne flavivirus that can lead to birth defects
(microcephaly), ocular lesions and neurological disorders (Guillain-Barré syndrome). There …

Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as
well as periodic pandemics. A complete understanding of the virus pathogenesis and host …

The lipid composition of the host cell membrane is one of the key determinants of the entry of
enveloped viruses into cells. To elucidate the detailed mechanisms behind the cell entry of …

Mosquito-borne flaviviruses are a group of RNA viruses that constitute global threats for
human and animal health. Replication of these pathogens is strictly dependent on cellular …