Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment

S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

[HTML][HTML] Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations

LF Yang, M Ling, N Kacherovsky, SH Pun - Chemical Science, 2023 - pubs.rsc.org
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …

Computational tools for aptamer identification and optimization

D Sun, M Sun, J Zhang, X Lin, Y Zhang, F Lin… - TrAC Trends in …, 2022 - Elsevier
Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …

[HTML][HTML] Capture-SELEX: selection strategy, aptamer identification, and biosensing application

SY Lam, HL Lau, CK Kwok - Biosensors, 2022 - mdpi.com
Small-molecule contaminants, such as antibiotics, pesticides, and plasticizers, have
emerged as one of the substances most detrimental to human health and the environment …

[HTML][HTML] Smart approach for the design of highly selective aptamer-based biosensors

A Douaki, D Garoli, AKMS Inam, MAC Angeli… - Biosensors, 2022 - mdpi.com
Aptamers are chemically synthesized single-stranded DNA or RNA oligonucleotides widely
used nowadays in sensors and nanoscale devices as highly sensitive biorecognition …

A review on magnetic beads-based SELEX technologies: Applications from small to large target molecules

I Manea, M Casian, O Hosu-Stancioiu… - Analytica Chimica …, 2024 - Elsevier
This review summarizes the stepwise strategy and key points for magnetic beads (MBs)-
based aptamer selection which is suitable for isolating aptamers against small and large …

[HTML][HTML] Modelling aptamers with nucleic acid mimics (NAM): From sequence to three-dimensional docking

R Oliveira, E Pinho, AL Sousa, Ó Dias, NF Azevedo… - Plos one, 2022 - journals.plos.org
Aptamers are single-stranded oligonucleotides, formerly evolved by Systematic Evolution of
Ligands by EXponential enrichment (SELEX), that fold into functional three-dimensional …

[HTML][HTML] Theoretical analysis of divalent cation effects on aptamer recognition of neurotransmitter targets

A Douaki, A Stuber, J Hengsteler… - Chemical …, 2023 - pubs.rsc.org
Aptamer-based sensing of small molecules such as dopamine and serotonin in the brain,
requires characterization of the specific aptamer sequences in solutions mimicking the in …

A novel electrochemical aptasensor based on polyaniline and gold nanoparticles for ultrasensitive and selective detection of ascorbic acid

C Jiang, L Xie, F Yan, Z Liang, J Liang, K Huang… - Analytical …, 2023 - pubs.rsc.org
Ascorbic acid (AA) is involved in many physiological activities of the body and plays an
important role in maintaining and promoting human health. It is also present in many natural …

[HTML][HTML] In-Silico Selection of Aptamer Targeting SARS-CoV-2 Spike Protein

YC Lin, WY Chen, ET Hwu, WP Hu - International Journal of Molecular …, 2022 - mdpi.com
Aptamers are single-stranded, short DNA or RNA oligonucleotides that can specifically bind
to various target molecules. To diagnose the infected cases of severe acute respiratory …