Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Mechanotransduction, the transformation of mechanical force into an electrical signal, allows
living organisms to hear, register movement and gravity, detect touch, and sense changes in …

Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …

Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …

Because there are currently no biological treatments for hearing loss, we sought to advance
gene therapy approaches to treat genetic deafness. We focused on Usher syndrome, a …

Hair cells of the inner ear are essential for hearing and balance. As a consequence,
pathogenic variants in genes specifically expressed in hair cells often cause hereditary …

Sensory transduction in auditory and vestibular hair cells requires expression of
transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is …

Inner ear hair cells convert the mechanical stimuli of sound, gravity, and head movement
into electrical signals. This mechanotransduction process is initiated by opening of cation …

Loss of cochlear hair cells in mammals is currently believed to be permanent, resulting in
hearing impairment that affects more than 10% of the population. Here, we developed two …

Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance.
The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for …