In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …

Like other autoimmune diseases, rheumatoid arthritis (RA) develops in distinct stages, with
each phase of disease linked to immune cell dysfunction. HLA class II genes confer the …

Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid
organs, providing both a structural matrix and soluble factors that regulate survival and …

Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic
rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other …

Objective In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA)
synovial tissue by training with gene expression data and machine learning. Methods …

Background Follicular structures resembling germinal centres (GCs) that are characterized
by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed …

Tertiary lymphoid organs (TLOs) are collections of immune cells resembling secondary
lymphoid organs (SLOs) that form in peripheral, non-lymphoid tissues in response to local …

RA is a heterogeneous clinical and pathobiological entity. Specific pathways within synovial
tissues are emerging as associated with diverse clinical evolution and therapeutic …

Rheumatoid arthritis is an autoimmune syndrome presenting with chronic inflammation of
the joints. Patients with the same diagnosis can present with different phenotypes. In some …