Gene therapy using nucleic acids has many clinical applications for the treatment of
diseases with a genetic origin as well as for the development of innovative vaccine …

Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

The current medical reality of cancer gene therapy is reflected by more than ten approved
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …

Optimizing synthetic nanocarriers is like searching for a needle in a haystack. How to find
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …

As an option for genetic disease treatment and an alternative for traditional cancer
chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however …

The introduction of the CRISPR/Cas9 system in the form of Cas9/sgRNA ribonucleoproteins
(RNP) is an efficient, straightforward strategy for genome editing, and potent RNP carriers …

A cationizable sequence-defined lipo-oligoaminoamide (lipo-OAA) conferring stable
assembly of siRNA into~ 200 nm sized complexes contains an N-terminal azidolysine for …

Gene therapy provides an alternative and effective method for treatment of genetic diseases
and cancers that are refractory to conventional therapeutics. The success of gene therapy is …

When optimizing nanocarriers, structural motifs that are beneficial for the respective type of
cargo need to be identified. Here, succinoyl tetraethylene pentamine (Stp)-based lipo …

Introduction: The whole delivery process of nucleic acids is very challenging. Appropriate
carrier systems are needed, which show extracellular stability and intracellular disassembly …