Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

Obesity and metabolic syndrome, with increased risk of eventual cardiovascular disease
and type II diabetes, are significant problems for patients receiving antipsychotic drugs and …

Imidazoles are an important class of heterocycles and include many substances of both
biological and chemical interest. They are part of a large number of highly significant …

A. Peripherally acting agents B. Centrally acting agents IV. Drugs That Alter Metabolism A.
Preabsorptive agents B. Postabsorptive modifiers of nutrient metabolism V. Drugs That …

Prescriptions for second-generation antipsychotics (SGAs) have surpassed those for first-
generation agents in the treatment of schizophrenia and bipolar disorder. While SGAs have …

Beside the therapeutic improvement over first-generation antipsychotics, the fact that
prescription of atypical agents is also associated to the emergence of severe metabolic …

Behavioral syndromes are suites of two or more behaviors that correlate across
environmental contexts. The aggression–boldness syndrome links aggression, boldness …

Within the recent years novel lead optimisations for histamine H3 receptor antagonists made
their way from bench to bedside. Structure–activity relationships, cross-affinities and side …

Ever since its pharmacologic discovery in 1983, 1 the histamine H3 receptor has provided a
tantalizing target for drug research, 25 years later still to be validated by an approved and …

Since the serendipitous discovery of the first antipsychotic (AP) drug in the 1950s, APs
remain the cornerstone of treatment for schizophrenia. A shift over the past two decades …