Functional mitochondria are critically important for the maintenance of cellular integrity and
survival. Mitochondrial dysfunction is a major contributor to neurodegenerative diseases …

Selective autophagy regulates the abundance of specific cellular components via a
specialized arsenal of factors, termed autophagy receptors, that target protein complexes …

Members of the Atg8 family of proteins are conjugated to autophagosomal membranes,
where they have been proposed to drive autophagosome formation and selective …

Serovars of Salmonella enterica cause both gastrointestinal and systemic diseases in a
broad range of mammalian hosts, including humans. Salmonella virulence depends in part …

Importance Recent genome-wide association studies (GWAS) and pathway analyses
supported long-standing observations of an association between immune-mediated …

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic
components, including cytosol and organelles, to the lysosome in double-membrane …

Autophagy is a major degradative process activated in a rapid and transient manner to cope
with stress conditions. Whether autophagy is beneficial or detrimental depends upon the …

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic
material in lysosomes. The process promotes cellular fidelity, and while the core machinery …

Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by
the lysosome. Maturation of autophagosomes requires their transport towards the …

Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …