Facioscapulohumeral muscular dystrophy (FSHD) is characterised by progressive skeletal
muscle weakness and wasting. FSHD is linked to epigenetic derepression of the …

Background Single-cell metabolic studies bring new insights into cellular function, which can
often not be captured on other omics layers. Metabolic information has wide applicability …

The network approach is quickly becoming a fundamental building block of computational
methods aiming at elucidating the mechanism of action (MoA) and therapeutic effect of …

Background Facioscapulohumeral dystrophy (FSHD) is a late‐onset autosomal dominant
form of muscular dystrophy involving specific groups of muscles with variable weakness that …

Biological markers (ie, biomarkers) is the key to predicting disease states and revealing the
molecular mechanisms in precision medicine of complex disease (eg, cancer). With the …

Background The accurate characterization of protein functions is critical to understanding life
at the molecular level and has a huge impact on biomedicine and pharmaceuticals …

Over the recent years, the SMCHD1 (Structural Maintenance of Chromosome flexible Hinge
Domain Containing 1) chromatin-associated factor has triggered increasing interest after the …

Evolution-based processes have been widely applied in bioengineering as well as in
cellular computing. For example, different approaches for protein evolution have been …

现有大多数用于识别候选疾病基因的随机游走方法通常优先访问高度连接的基因,
而可能与已知疾病有关的不知名或连接性差的基因易被忽略或难以识别. 此外 …

Modern civilization increasingly relies on sustainable and eco-friendly data centers as the
core hubs of intelligent computing. However, these data centers, while vital, also face …