Transposable elements and other repeats are repressed by small‐RNA‐guided histone
modifications in fungi, plants and animals. The specificity of silencing is achieved through …

During their development following sexual conjugation, ciliates excise numerous internal
eliminated sequences (IESs) from a copy of the germline genome to produce the functional …

Abstract The PIWI-interacting RNA (piRNA) pathway is crucial for transposon repression and
the maintenance of genomic integrity. Gametocyte-specific factor 1 (GTSF1), a PIWI …

Chromosome (SMC) proteins are a large family of ATPases that play important roles in the
organization and dynamics of chromatin. They are central regulators of chromosome …

Facultative heterochromatin is marked by the repressive histone modification H3K27me3 in
eukaryotes. Deposited by the PRC2 complex, H3K27me3 is essential for regulating gene …

Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their
functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia …

One of the most extensive forms of natural genome editing occurs in ciliates, a group of
microbial eukaryotes. Ciliate germline and somatic genomes are contained in distinct nuclei …

The unicellular eukaryote Paramecium tetraurelia contains functionally distinct nuclei:
germline micronuclei (MICs) and a somatic macronucleus (MAC). During sex, the MIC …

With its nuclear dualism, the ciliate Paramecium constitutes a unique model to study how
host genomes cope with transposable elements (TEs). P. tetraurelia harbors two germline …

Abstract 3D genome organization recapitulates genome function, typically at the level of
transcriptional state or chromatin state. Ciliates like Oxytricha trifallax possess highly …