Metagenomics and future perspectives in virus discovery

JL Mokili, F Rohwer, BE Dutilh - Current opinion in virology, 2012 - Elsevier
Monitoring the emergence and re-emergence of viral diseases with the goal of containing
the spread of viral agents requires both adequate preparedness and quick response …

Encapsulins

TW Giessen - Annual review of biochemistry, 2022 - annualreviews.org
Subcellular compartmentalization is a defining feature of all cells. In prokaryotes,
compartmentalization is generally achieved via protein-based strategies. The two main …

Multiple origins of viral capsid proteins from cellular ancestors

M Krupovic, EV Koonin - Proceedings of the National …, 2017 - National Acad Sciences
Viruses are the most abundant biological entities on earth and show remarkable diversity of
genome sequences, replication and expression strategies, and virion structures …

A virus capsid‐like nanocompartment that stores iron and protects bacteria from oxidative stress

CA McHugh, J Fontana, D Nemecek, N Cheng… - The EMBO …, 2014 - embopress.org
Living cells compartmentalize materials and enzymatic reactions to increase metabolic
efficiency. While eukaryotes use membrane‐bound organelles, bacteria and archaea rely …

Advances in encapsulin nanocompartment biology and engineering

JA Jones, TW Giessen - Biotechnology and bioengineering, 2021 - Wiley Online Library
Compartmentalization is an essential feature of all cells. It allows cells to segregate and
coordinate physiological functions in a controlled and ordered manner. Different …

Large-scale computational discovery and analysis of virus-derived microbial nanocompartments

MP Andreas, TW Giessen - Nature Communications, 2021 - nature.com
Encapsulins are a class of microbial protein compartments defined by the viral HK97-fold of
their capsid protein, self-assembly into icosahedral shells, and dedicated cargo loading …

Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin

Y Tang, A Mu, Y Zhang, S Zhou… - Proceedings of the …, 2021 - National Acad Sciences
Encapsulins containing dye-decolorizing peroxidase (DyP)-type peroxidases are ubiquitous
among prokaryotes, protecting cells against oxidative stress. However, little is known about …

Encapsulins—Bacterial protein nanocompartments: Structure, properties, and application

AN Gabashvili, NS Chmelyuk, MV Efremova… - Biomolecules, 2020 - mdpi.com
Recently, a new class of prokaryotic compartments, collectively called encapsulins or protein
nanocompartments, has been discovered. The shell proteins of these structures self …

Encapsulins: molecular biology of the shell

RJ Nichols, C Cassidy-Amstutz… - Critical Reviews in …, 2017 - Taylor & Francis
Compartmentalization is both a fundamental principle of cellular organization and an
emerging theme in prokaryotic biology. Work in the past few decades has shown that protein …

Encapsulins: microbial nanocompartments with applications in biomedicine, nanobiotechnology and materials science

TW Giessen - Current opinion in chemical biology, 2016 - Elsevier
Highlights•Encapsulins are a new class of microbial protein nanocompartments with
diameters of 24 or 32 nm.•They naturally encapsulate a variety of cargo proteins related to …