Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …

The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …

Microbial natural products are genetically encoded by dedicated biosynthetic gene clusters
(BGCs). A given BGC usually produces a family of related compounds that share a core but …

Biosynthesis of the DNA base thymine depends on activity of the enzyme thymidylate
synthase to catalyse the methylation of the uracil moiety of 2′-deoxyuridine-5 …

We review literature on the metabolism of ribo-and deoxyribonucleotides, nucleosides, and
nucleobases in Escherichia coli and Salmonella, including biosynthesis, degradation …

Dihydropyrimidine dehydrogenase (DPD) catalyzes the two-electron reduction of pyrimidine
bases uracil and thymine as the first step in pyrimidine catabolism. The enzyme achieves …

Taking the emergence of drug resistance and lack of effective antimalarial vaccines into
consideration, it is of significant importance to develop novel antimalarial agents for the …

Plasmodium falciparum dihydroorotate dehydrogenase (pf DHODH) is a flavin-dependent
mitochondrial enzyme that provides the only route to pyrimidine biosynthesis in the parasite …

Dihydroorotate dehydrogenase (DHOD) from Trypanosoma cruzi (TcDHOD) is a member of
family 1A DHOD that catalyzes the oxidation of dihydroorotate to orotate (first half-reaction) …

For several decades only one chemical pathway was known for the de novo biosynthesis of
the essential DNA nucleotide, thymidylate. This reaction catalyzed by thyA or TYMS …