The emerging field of oncolytic virus-based cancer immunotherapy

R Ma, Z Li, EA Chiocca, MA Caligiuri, J Yu - Trends in cancer, 2023 - cell.com
Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

[HTML][HTML] Oncolytic viruses: a new class of immunotherapy drugs

HL Kaufman, FJ Kohlhapp, A Zloza - Nature reviews Drug discovery, 2015 - nature.com
Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …

[HTML][HTML] Cancer immunotherapy: the beginning of the end of cancer?

S Farkona, EP Diamandis, IM Blasutig - BMC medicine, 2016 - Springer
These are exciting times for cancer immunotherapy. After many years of disappointing
results, the tide has finally changed and immunotherapy has become a clinically validated …

Oncolytic viruses in cancer treatment: a review

SE Lawler, MC Speranza, CF Cho, EA Chiocca - JAMA oncology, 2017 - jamanetwork.com
Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

[HTML][HTML] Oncolytic viruses and the immune system: the dynamic duo

AL De Matos, LS Franco, G McFadden - Molecular Therapy-Methods & …, 2020 - cell.com
Oncolytic viruses (OVs) constitute a new and promising immunotherapeutic approach
toward cancer treatment. This therapy takes advantage of the natural propensity of most …

[HTML][HTML] Advances in immunotherapy for glioblastoma multiforme

AB Mahmoud, R Ajina, S Aref, M Darwish… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor
of the central nervous system and has a very poor prognosis. The current standard of care …

Talimogene laherparepvec (T-VEC) and other oncolytic viruses for the treatment of melanoma

PK Bommareddy, A Patel, S Hossain… - American journal of …, 2017 - Springer
Many mammalian viruses have properties that can be commandeered for the treatment of
cancer. These characteristics include preferential infection and replication in tumor cells, the …

Oncolytic viruses and their application to cancer immunotherapy

EA Chiocca, SD Rabkin - Cancer immunology research, 2014 - AACR
Oncolytic viruses (OV) selectively replicate and kill cancer cells and spread within the tumor,
while not harming normal tissue. In addition to this direct oncolytic activity, OVs are also very …

Emerging nano-/biotechnology drives oncolytic virus-activated and combined cancer immunotherapy

C Fang, G Xiao, T Wang, L Song, B Peng, B Xu… - Research, 2023 - spj.science.org
Oncolytic viruses (OVs) as one promising antitumor methods have made important
contributions to tumor immunotherapy, which arouse increasing attention. They provide the …

[HTML][HTML] Oncolytic viruses as therapeutic cancer vaccines

DL Bartlett, Z Liu, M Sathaiah, R Ravindranathan… - Molecular cancer, 2013 - Springer
Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …