Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …

The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …

This review aims to provide an overview of recent developments regarding the roles of
MMPs in tumour invasion and metastasis. Much of the mortality burden belonging to cancer …

Epidermal growth factor receptor (EGFR) is highly expressed in certain cancer types and is
involved in regulating the biological characteristics of cancer progression, including …

The ESCRT machinery is an ancient, evolutionarily conserved membrane remodelling
complex that is deployed by cells to perform a diverse collection of physiological and …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

Highlights•Actin polymerization on endosomes is primarily controlled by the regulation of the
WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and …

Activation of the JAK–STAT pathway by type I interferons (IFNs) requires clathrin-dependent
endocytosis of the IFN-α and-β receptor (IFNAR), indicating a role for endosomal sorting in …

Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …