Viral pathogens often induce strong effector CD4+ T cell responses that are best known for
their ability to help B cell and CD8+ T cell responses. However, recent studies have …

Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and …

CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are
presented on target cells by the class I major histocompatibility complex. CTLs are …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

▪ Abstract CD40-CD154–mediated contact-dependent signals between B and T cells are
required for the generation of thymus dependent (TD) humoral immune responses. CD40 …

Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority
of the responding T cells has not been defined. To address this issue we used tetramers of …

Abstract Type I interferons (IFN-I) are rapidly induced following infection and play a key role
in nonspecific inhibition of virus replication. Here we have investigated the effects of IFN-I on …

The Traf-linked tumor necrosis factor receptor family member CD27 is known as a T cell
costimulatory molecule. We generated CD27−/− mice and found that CD27 makes essential …

Cytotoxic T lymphocytes (CTLs) that express the CD8 co-receptor are the guided missiles of
the immune system. They express clonally distributed receptors for foreign antigen, undergo …