ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

Background Osteoarthritis (OA) is the most common joint disease and is the leading cause
of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

Macroautophagy (hereafter referred to as autophagy) involves an intracellular degradation
and recycling system that, in a context-dependent manner, can either promote cell survival …

The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …

The most common cause of death in the intensive care unit (ICU) is the development of
multiorgan dysfunction syndrome (MODS). Besides life-supporting treatments, no cure …

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …

Amyotrophic lateral sclerosis (ALS) is caused by selective degeneration of motor neurons in
the brain and spinal cord; however, the primary cell death pathway (s) mediating motor …