Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised
by deficits in social communication and restricted or repetitive behaviours. The clinical …

Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and
neurons in the central nervous system. Peripheral or central inflammation is characterized …

Acute infection, if not kept in check, can lead to systemic inflammatory responses in the
brain. Here, we show that within 2 hr of systemic inflammation, PDGFRβ mural cells of blood …

It is increasingly clear that systemic inflammation has both adaptive and deleterious effects
on the brain. However, detailed comparisons of brain effects of systemic challenges with …

Autism is a disorder of neurobiological origin characterized by problems in communication
and social skills and repetitive behavior. After more than six decades of research, the …

Aims This open‐label prospective phase I/II a clinical study used autologous bone marrow‐
derived mesenchymal stromal cells (BM‐MSC s) followed by mesenchymal stromal cells …

The chemokine system mediates acute inflammation by driving leukocyte migration to
damaged or infected tissues. However, elevated expression of chemokines and their …

A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …

While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

Background Monocyte chemoattractant protein (CCL2/MCP-1) is a chemokine that attracts
cells involved in the immune/inflammatory response. As microglia are one of the main cell …