States. The disease results from exceSS cholesterol accumu lation in the arterial walls,
which forms plaques that inhibit blood flow and promote clot formation, ultimately causing …

Atherosclerosis is a leading cause of death in the United States. The disease results from
excess cholesterol accumu lation in the arterial Walls, Which forms plaques that inhibit blood …

The present invention provides novel compositions of allos teric hemoglobin modifiers which
are substantially free of impurities, specifically polymeric impurities. In one embodiment, the …

57 ABSTRACT A family of compounds has been found to be useful for right-shifting
hemoglobin towards a low oxygen affinity state. The effect has particular application in a …

WO2003086324A2 - Preparation and use of a stable formulation of allosteric effector
compounds - Google Patents WO2003086324A2 - Preparation and use of a stable …

2005-03-23 Assigned to VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL
PROPERTY FOUNDATION reassignment VIRGINIA COMMONWEALTH UNIVERSITY …

[57] ABSTRACT A family of compounds has been found to be useful for right-shifting
hemoglobin towards a low oxygen affinity state. The effect has particular application in …

30, 1993, Pat. No. 5,432,191, which is a continuation-in-part Attorney, Agent, or Firm
Whitham, Curtis & Whitham of application No. 08/006,246, Jan. 19, 1993, Pat. No …

US PATENT DOCUMENTS 2.913, 454 A 11, 1959 Petersen et al. 3,723.442 A 3, 1973
Nakanishi et al. 3,784,551 A 1/1974 Nakanishi et al. 4,350,696 A 9, 1982 Cross et al …

The use of substituted amides for modulating the activity of 11-hydroxysteroid
dehydrogenase type 1 (11 HSD1) and the use of these compounds as pharmaceutical …