The inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn disease, are
chronic inflammatory disorders of the gastrointestinal tract most often diagnosed in …

Background Inflammatory bowel diseases [IBD]―ulcerative colitis and Crohn's disease―are
commonly treated with biologic drugs. However, only approximately two-thirds of patients …

Objective We aimed to provide an evidence-supported update of the ECCO-ESPGHAN
guideline on the medical management of paediatric Crohn's disease [CD]. Methods We …

Children and adolescents with Crohn's disease (CD) present often with a more complicated
disease course compared to adult patients. In addition, the potential impact of CD on growth …

Objectives A systematic review was conducted to explore the immunogenicity of biologic
agents across inflammatory diseases and its potential impact on efficacy/safety. Methods …

Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and
systemic flushing accompanied by extensive sterile pustules. The committee of the …

Background Nonresponse and loss of response to anti‐TNF therapies in Crohn's disease
represent significant clinical problems for which clear management guidelines are lacking …

Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …

Anti-tumour necrosis factor (TNF) antibodies have been widely used for approximately 25
years now. The first clinical observations in patients with refractory Crohn's disease rapidly …

Aliment Pharmacol Ther 2011; 33: 987–995 Summary Background Loss of response to anti‐
TNF agents in Crohn's disease is an emerging clinical problem. Aim To review the causes …