A comprehensive review on tyrosinase inhibitors

S Zolghadri, A Bahrami, MT Hassan Khan… - Journal of enzyme …, 2019 - Taylor & Francis
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Natural and bioinspired phenolic compounds as tyrosinase inhibitors for the treatment of skin hyperpigmentation: Recent advances

L Panzella, A Napolitano - Cosmetics, 2019 - mdpi.com
One of the most common approaches for control of skin pigmentation involves the inhibition
of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis …

Color and molecular structure alterations of brazilein extracted from Caesalpinia sappan L. under different pH and heating conditions

L Ngamwonglumlert, S Devahastin, N Chiewchan… - Scientific reports, 2020 - nature.com
Brazilein extract from sappan wood (Caesalpinia sappan L.) has potential for use as natural
food colorant since it has no unique flavor and taste. Although brazilein has long been …

Naturally-occurring tyrosinase inhibitors classified by enzyme kinetics and copper chelation

HD Kim, H Choi, F Abekura, JY Park, WS Yang… - International Journal of …, 2023 - mdpi.com
Currently, there are three major assaying methods used to validate in vitro whitening activity
from natural products: methods using mushroom tyrosinase, human tyrosinase, and …

Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin

Y Fu, AM Alashi, JF Young, M Therkildsen… - International journal of …, 2017 - Elsevier
In this work, the inhibitory effects of potato patatin-derived peptides Trp-Gly (WG) and Pro-
Arg-Tyr (PRY) on angiotensin I-converting enzyme (ACE) and renin activities were …

Mushroom (Agaricus bisporus) polyphenoloxidase inhibited by apigenin: Multi-spectroscopic analyses and computational docking simulation

Z Xiong, W Liu, L Zhou, L Zou, J Chen - Food Chemistry, 2016 - Elsevier
It has been revealed that some polyphenols can prevent enzymatic browning caused by
polyphenoloxidase (PPO). Apigenin, widely distributed in many fruits and vegetables, is an …

Structure and inhibition mechanism of some synthetic compounds and phenolic derivatives as tyrosinase inhibitors: Review and new insight

M Vaezi - Journal of Biomolecular Structure and Dynamics, 2023 - Taylor & Francis
Safety concerns are the primary consideration to identify and detection of enzyme inhibitors.
In this regard, safe and potent tyrosinase inhibitors play important role in enhancing …

Detection of misdistribution of tyrosinase from melanosomes to lysosomes and its upregulation under psoralen/ultraviolet a with a melanosome-targeting tyrosinase …

J Zhou, W Shi, L Li, Q Gong, X Wu, X Li… - Analytical chemistry, 2016 - ACS Publications
Tyrosinase is regarded as an important biomarker of melanoma cancer, and its metabolism
is closely related to some severe skin diseases such as vitiligo. Since tyrosinase is mainly …

Inhibitory mechanism of scutellarein on tyrosinase by kinetics, spectroscopy and molecular simulation

Q Chen, C Shang, M Han, C Chen, W Tang… - Spectrochimica Acta Part …, 2023 - Elsevier
Tyrosinase plays an important role in melanin synthesis. Inhibition against tyrosinase activity
has been extensively focused on for pharmaceutical, food, cosmetic, and agricultural …

Unraveling the inhibition mechanism of cyanidin-3-sophoroside on polyphenol oxidase and its effect on enzymatic browning of apples

H Hemachandran, A Anantharaman, S Mohan… - Food Chemistry, 2017 - Elsevier
The hunt for anti-browning agents in the food and agricultural industries aims to minimize
nutritional loss and prolong post harvest storage. In the present study, the effect of cyanidin …