Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …

Several highly effective, interferon‐free, direct‐acting antiviral (DAA)‐based regimens are
available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive …

The extracellular signal-regulated kinase (ERK) pathway leads to activation of the effector
molecule ERK, which controls downstream responses by phosphorylating a variety of …

Animal development is characterized by signaling events that occur at precise locations and
times within the embryo, but determining when and where such precision is needed for …

Cell signaling networks coordinate specific patterns of protein expression in response to
external cues, yet the logic by which signaling pathway activity determines the eventual …

Metastasis is the leading cause of death in people with lung cancer, yet the molecular
effectors underlying tumor dissemination remain poorly defined. Through the development …

The Erk mitogen-activated protein kinase plays diverse roles in animal development. Its
widespread reuse raises a conundrum: when a single kinase like Erk is activated, how does …

Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs).
Following damage or stress the intestinal epithelium produces ligands that activate the …

Hepatocellular carcinoma (HCC) is developed by multiple steps accompanying progressive
alterations of gene expression, which leads to increased cell proliferation and malignancy …

Optogenetic perturbations, live imaging, and time-resolved ChIP-seq assays in Drosophila
embryos were used to dissect the ERK-dependent control of the HMG-box repressor …