Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact analysis …
P Gentile, S Garcovich - Cells, 2019 - mdpi.com
The use of stem cells has been reported to improve hair regrowth in several therapeutic
strategies, including reversing the pathological mechanisms, that contribute to hair loss …
strategies, including reversing the pathological mechanisms, that contribute to hair loss …
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
Reorganization of enhancer patterns in transition from naive to primed pluripotency
Naive and primed pluripotency is characterized by distinct signaling requirements,
transcriptomes, and developmental properties, but both cellular states share key …
transcriptomes, and developmental properties, but both cellular states share key …
Core transcriptional regulatory circuitry in human embryonic stem cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early
development and are required for the propagation of undifferentiated embryonic stem (ES) …
development and are required for the propagation of undifferentiated embryonic stem (ES) …
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
I Chambers, D Colby, M Robertson, J Nichols, S Lee… - Cell, 2003 - cell.com
Embryonic stem (ES) cells undergo extended proliferation while remaining poised for
multilineage differentiation. A unique network of transcription factors may characterize self …
multilineage differentiation. A unique network of transcription factors may characterize self …
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-
renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end …
renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end …
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
Blastocyst formation marks the segregation of the first two cell lineages in the mammalian
preimplantation embryo: the inner cell mass (ICM) that will form the embryo proper and the …
preimplantation embryo: the inner cell mass (ICM) that will form the embryo proper and the …
BMP4 initiates human embryonic stem cell differentiation to trophoblast
RH Xu, X Chen, DS Li, R Li, GC Addicks… - Nature …, 2002 - nature.com
The excitement and controversy surrounding the potential role of human embryonic stem
(ES), cells in transplantation therapy have often overshadowed their potentially more …
(ES), cells in transplantation therapy have often overshadowed their potentially more …
Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells
H Kubota, MR Avarbock… - Proceedings of the …, 2004 - National Acad Sciences
Spermatogonial stem cells (SSCs) self-renew and produce large numbers of committed
progenitors that are destined to differentiate into spermatozoa throughout life. However, the …
progenitors that are destined to differentiate into spermatozoa throughout life. However, the …