Genetics and epigenetics of gastroenteropancreatic neuroendocrine neoplasms

A Mafficini, A Scarpa - Endocrine reviews, 2019 - academic.oup.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

MicroRNAs in placental health and disease

JF Mouillet, Y Ouyang, CB Coyne… - American journal of …, 2015 - Elsevier
MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded
by the genomes of most organisms. They regulate gene expression through …

Global mapping of human RNA-RNA interactions

E Sharma, T Sterne-Weiler, D O'Hanlon, BJ Blencowe - Molecular cell, 2016 - cell.com
The majority of the human genome is transcribed into non-coding (nc) RNAs that lack known
biological functions or else are only partially characterized. Numerous characterized …

Immune modulatory microRNAs involved in tumor attack and tumor immune escape

SB Eichmüller, W Osen, O Mandelboim… - JNCI: Journal of the …, 2017 - academic.oup.com
Current therapies against cancer utilize the patient's immune system for tumor eradication.
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …

[HTML][HTML] Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells

MN Wosczyna, EEP Carbajal, MW Wagner, S Paredes… - Cell Stem Cell, 2021 - cell.com
Intramuscular fatty deposits, which are seen in muscular dystrophies and with aging,
negatively affect muscle function. The cells of origin of adipocytes constituting these fatty …

Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome

KF Hansen, K Sakamoto, S Aten, KH Price… - Learning & …, 2016 - learnmem.cshlp.org
miR-132 and miR-212 are structurally related microRNAs that have been found to exert
powerful modulatory effects within the central nervous system (CNS). Notably, these …

Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer

D Fan, B Ren, X Yang, J Liu, Z Zhang - Journal of Experimental & Clinical …, 2016 - Springer
Background miRNAs are critical post-transcriptional regulators of gene expression and key
mediators of tumourigenesis. miR-501-5p is newly identified to be involved in the tumor …

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

C Herskind, CJ Talbot, SL Kerns, MR Veldwijk… - Cancer letters, 2016 - Elsevier
Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to
tumour cells. Since 80% of individual variation in clinical response is estimated to be caused …

LncRNA COL1A1-014 is involved in the progression of gastric cancer via regulating CXCL12-CXCR4 axis

XZ Dong, ZR Zhao, Y Hu, YP Lu, P Liu, L Zhang - Gastric Cancer, 2020 - Springer
Background The aberrant expression of long noncoding RNAs (lncRNAs) is found in various
types of cancers and also showed its association with the occurrence and development of …

MicroRNA target prediction tools for animals: Where we are at and where we are going to-A systematic review

RMMW Feitosa, P Prieto-Oliveira, H Brentani… - … Biology and Chemistry, 2022 - Elsevier
MicroRNAs (miRNAs) are non-coding RNAs containing 19–26 nucleotides, and they directly
regulate the translation of mRNAs by binding to them. MiRNAs participate in various …