Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Immunomodulatory properties of mesenchymal stromal cells: an update

L Müller, A Tunger, M Wobus, M von Bonin… - Frontiers in cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are characterized by an extraordinary capacity to
modulate the phenotype and functional properties of various immune cells that play an …

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response

AC Court, A Le‐Gatt, P Luz‐Crawford, E Parra… - EMBO …, 2020 - embopress.org
Mesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune‐
mediated diseases. They exert immunoregulatory and tissue‐restoring effects. MSC …

Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis

S Takeuchi, A Tsuchiya, T Iwasawa, S Nojiri… - NPJ Regenerative …, 2021 - nature.com
Mesenchymal stromal cells (MSCs) are used for ameliorating liver fibrosis and aiding liver
regeneration after cirrhosis; Here, we analyzed the therapeutic potential of small …

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function

G Beldi, M Khosravi, ME Abdelgawad… - Stem cell research & …, 2020 - Springer
Background In addition to their multilineage potential, mesenchymal stem cells (MSCs) have
a broad range of functions from tissue regeneration to immunomodulation. MSCs have the …

TNFR2 is a crucial hub controlling mesenchymal stem cell biological and functional properties

G Beldi, S Bahiraii, C Lezin… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) have drawn lots of attention as gold standard stem cells in
fundamental and clinical researches during the last 20 years. Due to their tissue and …

Regulatory T cell induction by mesenchymal stem cells depends on the expression of TNFR2 by T cells

S Naserian, S Shamdani, N Arouche… - Stem cell research & …, 2020 - Springer
Mesenchymal stem/stromal cells can modulate the effector immune cells especially T
lymphocytes. Due to this important feature, they can regulate the development of a variety of …

[HTML][HTML] Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells

M Razazian, M Khosravi, S Bahiraii… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
Bone-marrow-derived mesenchymal stem cells and endothelial progenitor cells have some
interesting biological properties that make them unique for cell therapy of degenerative and …

Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity

Y Yu, AV Valderrama, Z Han, G Uzan… - Stem cell research & …, 2021 - Springer
Abstract Background Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or
modulate deleterious immune responses by various molecular mechanisms. These cells are …

Induction of CD4+CD25+FOXP3+ regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation

M Khosravi, A Bidmeshkipour, JL Cohen… - Stem Cell Research & …, 2018 - Springer
Abstract Background Mesenchymal stem cells (MSCs) are known for their ability to induce
the conversion of conventional T cells (Tconvs) into induced regulatory T cells (iTregs) in …