The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1
(GH/IGF-1) axis are associated with increased life-and healthspan across model organisms …

Abstract Insulin-like Growth Factor 1 (IGF-1) and its signaling pathway play a primary role in
normal growth and ageing, however serum IGF-1 is known to reduce with advancing age …

I. Introduction T HE PRESENCE of GH-inhibitory substances in hypothalamic extracts was
originally detected accidentally by Krulich et al.(1) during investigations into the distribution …

Somatomedin preparations have previously been shown to suppress GH release. The
effects of a synthetic recombinant human insulin-like growth factor analog (IGF-I; Thr 59) …

We have developed a pure cortical neuronal culture free of glial cells, grown in a serum-free
environment. The cultured cells immunostained positively with neurofilament antibody while …

Growth hormone (GH) secretion in children and adults is profoundly, but reversibly,
suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of …

We have evaluated the plasma GH response to a single injection of 1μg/kg of GH‐releasing
hormone (GHRH)‐40 in 15 obese children and 15 age‐matched control children. Most of the …

The endocrine system has to balance the counteracting processes of protein synthesis and
degradation. Moreover, it has to ensure that the increase in muscle mass is also balanced …

We have previously shown that insulinlike growth factor I (IGF-I) inhibits growth hormone
(GH) secretion and messenger RNA (mRNA) levels in pituitary cells. The effects of IGF-I on …