Molecular aspects of varicella-zoster virus latency

DP Depledge, T Sadaoka, WJD Ouwendijk - Viruses, 2018 - mdpi.com
Primary varicella-zoster virus (VZV) infection causes varicella (chickenpox) and the
establishment of a lifelong latent infection in ganglionic neurons. VZV reactivates in about …

Clinical and molecular pathogenesis of varicella virus infection

DH Gilden, RJ Cohrs, R Mahalingam - Viral immunology, 2003 - liebertpub.com
Varicella zoster virus (VZV) is a neurotropic human herpesvirus that infects nearly all
humans and causes chickenpox (varicella). After chickenpox, VZV becomes latent in cranial …

Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus

Y Gomi, H Sunamachi, Y Mori, K Nagaike… - Journal of …, 2002 - Am Soc Microbiol
The DNA sequences of the Oka varicella vaccine virus (V-Oka) and its parental virus (P-Oka)
were completed. Comparison of the sequences revealed 42 base substitutions, which led to …

Aberrant intracellular localization of varicella-zoster virus regulatory proteins during latency

O Lungu, CA Panagiotidis… - Proceedings of the …, 1998 - National Acad Sciences
Varicella-Zoster virus (VZV) is a herpesvirus that becomes latent in sensory neurons after
primary infection (chickenpox) and subsequently may reactivate to cause zoster. The …

Varicella-zoster virus retains major histocompatibility complex class I proteins in the Golgi compartment of infected cells

A Abendroth, I Lin, B Slobedman, H Ploegh… - Journal of …, 2001 - Am Soc Microbiol
We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression
of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T …

Long-read sequencing uncovers a complex transcriptome topology in varicella zoster virus

I Prazsák, N Moldován, Z Balázs, D Tombácz… - BMC genomics, 2018 - Springer
Background Varicella zoster virus (VZV) is a human pathogenic alphaherpesvirus harboring
a relatively large DNA molecule. The VZV transcriptome has already been analyzed by …

Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for …

RJ Cohrs, M Barbour, DH Gilden - Journal of virology, 1996 - Am Soc Microbiol
Information on the extent of virus DNA transcription and translation in infected tissue is
crucial to an understanding of herpesvirus latency. To detect low-abundance latent varicella …

Modulation of major histocompatibility class II protein expression by varicella-zoster virus

A Abendroth, B Slobedman, E Lee, E Mellins… - Journal of …, 2000 - Am Soc Microbiol
We sought to investigate the effects of varicella-zoster virus (VZV) infection on gamma
interferon (IFN-γ)-stimulated expression of cell surface major histocompatibility complex …

Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor

Z Zhang, A Selariu, C Warden, G Huang… - PLoS …, 2010 - journals.plos.org
The Varicella Zoster Virus (VZV) is a ubiquitous human alpha-herpesvirus that is the
causative agent of chicken pox and shingles. Although an attenuated VZV vaccine (v-Oka) …

The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection

A Narayanan, WT Ruyechan… - Proceedings of the …, 2007 - National Acad Sciences
Originally identified as an essential component of the herpes simplex virus immediate early
(IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has …