Molecular and cellular basis of genetically inherited skeletal muscle disorders
JJ Dowling, CC Weihl, MJ Spencer - Nature Reviews Molecular Cell …, 2021 - nature.com
Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …
Macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases
Muscle regeneration is a closely regulated process that involves a variety of cell types such
as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory …
as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory …
[HTML][HTML] Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer
Y Ozato, Y Kojima, Y Kobayashi, Y Hisamatsu… - Cell reports, 2023 - cell.com
The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are
poorly understood, hindering patient treatment. In the current study, we investigate whether …
poorly understood, hindering patient treatment. In the current study, we investigate whether …
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma
Y Zhang, W Du, Z Chen, C Xiang - Experimental cell research, 2017 - Elsevier
Tumor-associated macrophages (TAMs) polarization represents a key regulatory process of
tumor progression. However, the underlying mechanisms are unclear. This study aimed to …
tumor progression. However, the underlying mechanisms are unclear. This study aimed to …
Osteopontin in vascular disease: Friend or foe?
ZSY Lok, AN Lyle - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …
healing process. However, when this acute response does not resolve and becomes …
[HTML][HTML] The role of innate and adaptive immune cells in skeletal muscle regeneration
Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide
variety of innate and adaptive immune cells orchestrate the complex process of muscle …
variety of innate and adaptive immune cells orchestrate the complex process of muscle …
Inflammatory response to magnesium-based biodegradable implant materials
MD Costantino, A Schuster, H Helmholz… - Acta biomaterialia, 2020 - Elsevier
Biodegradability and mechanical properties of magnesium alloys are attractive for
orthopaedic and cardiovascular applications. In order to study their cytotoxicity usually bone …
orthopaedic and cardiovascular applications. In order to study their cytotoxicity usually bone …
[HTML][HTML] Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M
P Zhou, D Xia, Z Ni, T Ou, Y Wang, H Zhang, L Mao… - Bioactive materials, 2021 - Elsevier
Immune reactions are a key factor in determining the destiny of bone substitute materials
after implantation. Macrophages, the most vital factor in the immune response affecting …
after implantation. Macrophages, the most vital factor in the immune response affecting …
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15
A Patsalos, L Halasz, MA Medina-Serpas… - Journal of Experimental …, 2021 - rupress.org
Muscle regeneration is the result of the concerted action of multiple cell types driven by the
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …