Molecular and cellular basis of genetically inherited skeletal muscle disorders

JJ Dowling, CC Weihl, MJ Spencer - Nature Reviews Molecular Cell …, 2021 - nature.com
Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

Macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases

J Dort, P Fabre, T Molina, NA Dumont - Stem cells international, 2019 - Wiley Online Library
Muscle regeneration is a closely regulated process that involves a variety of cell types such
as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory …

[HTML][HTML] Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer

Y Ozato, Y Kojima, Y Kobayashi, Y Hisamatsu… - Cell reports, 2023 - cell.com
The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are
poorly understood, hindering patient treatment. In the current study, we investigate whether …

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma

Y Zhang, W Du, Z Chen, C Xiang - Experimental cell research, 2017 - Elsevier
Tumor-associated macrophages (TAMs) polarization represents a key regulatory process of
tumor progression. However, the underlying mechanisms are unclear. This study aimed to …

Osteopontin in vascular disease: Friend or foe?

ZSY Lok, AN Lyle - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …

[HTML][HTML] The role of innate and adaptive immune cells in skeletal muscle regeneration

N Ziemkiewicz, G Hilliard, NA Pullen… - International journal of …, 2021 - mdpi.com
Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide
variety of innate and adaptive immune cells orchestrate the complex process of muscle …

Inflammatory response to magnesium-based biodegradable implant materials

MD Costantino, A Schuster, H Helmholz… - Acta biomaterialia, 2020 - Elsevier
Biodegradability and mechanical properties of magnesium alloys are attractive for
orthopaedic and cardiovascular applications. In order to study their cytotoxicity usually bone …

[HTML][HTML] Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M

P Zhou, D Xia, Z Ni, T Ou, Y Wang, H Zhang, L Mao… - Bioactive materials, 2021 - Elsevier
Immune reactions are a key factor in determining the destiny of bone substitute materials
after implantation. Macrophages, the most vital factor in the immune response affecting …

A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15

A Patsalos, L Halasz, MA Medina-Serpas… - Journal of Experimental …, 2021 - rupress.org
Muscle regeneration is the result of the concerted action of multiple cell types driven by the
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …