Strategic design and fabrication of engineered scaffolds for articular cartilage repair

Z Izadifar, X Chen, W Kulyk - Journal of functional biomaterials, 2012 - mdpi.com
Damage to articular cartilage can eventually lead to osteoarthritis (OA), a debilitating,
degenerative joint disease that affects millions of people around the world. The limited …

Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs

TBF Woodfield, CAV Blitterswijk, JD Wijn… - Tissue …, 2005 - liebertpub.com
The zonal organization of cells and extracellular matrix (ECM) constituents within articular
cartilage is important for its biomechanical function in diarthroidal joints. Tissue-engineering …

Perspective in achieving stratified articular cartilage repair using zonal chondrocytes

CA Tee, J Han, JHP Hui, EH Lee… - Tissue Engineering Part B …, 2023 - liebertpub.com
Articular cartilage is composed of superficial, medial, and deep zones, which endow the
tissue with biphasic mechanical properties to withstand shearing force and compressional …

A pre-clinical animal study for zonal articular cartilage regeneration using stratified implantation of microcarrier expanded zonal chondrocytes

CA Tee, Z Yang, Y Wu, X Ren, M Baranski, DJ Lin… - Cartilage, 2022 - journals.sagepub.com
Objective The zonal properties of articular cartilage critically contribute to the mechanical
support and lubrication of the tissue. Current treatments for articular cartilage have yet to …

Application of Size-Based Sorted Zonal Chondrocytes for Articular Cartilage Repair

TC Ann - 2020 - search.proquest.com
Background: The zonal property of articular cartilage endows the tissue with biphasic
mechanical properties to withstand shearing force and compressional loading. Current …