There is an increasing interest in nootropic drugs for the treatment of CNS disorders. Since
the last meta-analysis of the clinical efficacy of piracetam, more information has …

Piracetam, a derivative of the neurotransmitter γ‐aminobutyric acid (GABA), has a variety of
physiological effects that may result, at least in part, from the restoration of cell membrane …

Myoclonus presents as a sudden brief jerk caused by involuntary muscle activity. An
organisational framework is crucial for determining the medical significance of the …

Background: Currently, there are no published randomized controlled trials evaluating the
efficacy and safety of adjunctive antiepileptic therapy in idiopathic generalized epilepsy with …

Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

This article is the third and last in a series entitled The Finnish Disease Heritage I–III. All the
36 rare hereditary diseases belonging to this entity are described for clinical and molecular …

Myoclonus creates significant disability for patients. This symptom or sign can have many
different etiologies, presentations, and pathophysiological mechanisms. A thorough …

Purpose: To assess the long‐term evolution of Unverricht–Lundborg disease (ULD),
especially concerning myoclonus, seizures, and EEG characteristics. Methods: We …

Nootropics represent probably the first “smart drugs” used for the treatment of cognitive
deficits. The aim of this paper is to verify, by a systematic analysis of the literature, the …

Lafora disease is a rare and fatal disease characterized by seizures, progressive cognitive
and behavioral deterioration, as well as cerebellar dysfunction. Currently, there is no …