Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

An artificial intelligence framework and its bias for brain tumor segmentation: A narrative review

S Das, GK Nayak, L Saba, M Kalra, JS Suri… - Computers in biology and …, 2022 - Elsevier
Background Artificial intelligence (AI) has become a prominent technique for medical
diagnosis and represents an essential role in detecting brain tumors. Although AI-based …

Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

Role of melatonin in controlling angiogenesis under physiological and pathological conditions

Q Ma, RJ Reiter, Y Chen - Angiogenesis, 2020 - Springer
Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

SD Stojanović, J Fiedler, J Bauersachs… - European Heart …, 2020 - academic.oup.com
Inflammation is a hallmark and potent driver of pathological vascular remodelling in
atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown …

Blood vessel organoids for development and disease

K Salewskij, JM Penninger - Circulation Research, 2023 - Am Heart Assoc
Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …

[HTML][HTML] Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis

Q Xue, N He, Z Wang, X Fu, LHH Aung, Y Liu… - Journal of ginseng …, 2021 - Elsevier
Atherosclerosis (AS) is a leading cause of cardiovascular diseases (CVDs) and it results in a
high rate of death worldwide, with an increased prevalence with age despite advances in …

Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence

PK Lin, GE Davis - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
Because of structural and cellular differences (ie, degrees of matrix abundance and cross-
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …

Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets

L Badimon, T Padro, G Arderiu, G Vilahur… - Immunological …, 2022 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global
mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular …

Inflammation, oxidative stress, senescence in atherosclerosis: thioredoxine-1 as an emerging therapeutic target

K El Hadri, R Smith, E Duplus, C El Amri - International journal of …, 2021 - mdpi.com
Atherosclerosis is a leading cause of cardiovascular diseases (CVD) worldwide and
intimately linked to aging. This pathology is characterized by chronic inflammation, oxidative …