Abstract Changes to the conformation of coding and non-coding RNAs form the basis of
elements of genetic regulation and provide an important source of complexity, which drives …

Pseudouridine synthases are the enzymes responsible for the most abundant
posttranscriptional modification of cellular RNAs. These enzymes catalyze the site-specific …

RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …

Riboswitches are RNA sensors that have been shown to modulate the expression of
downstream genes by altering their structure upon metabolite binding. Riboswitches are …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

The regulation of cell signaling pathways and the reconstruction of genetic circuits are
important aspects of bioengineering research. Both of these goals require molecular devices …

Summary H/ACA RNA-protein complexes, comprised of four proteins and an H/ACA guide
RNA, modify ribosomal and small nuclear RNAs. The H/ACA proteins are also essential …

Synthetic nanostructures consisting of biomacromolecules such as nucleic acids have been
constructed using bottom-up approaches,. In particular, Watson–Crick base pairing has …

Feedback regulation plays a crucial role in dynamic gene expression in nature, but synthetic
translational feedback systems have yet to be demonstrated. Here we use an RNA/protein …

Molecular machines composed of RNA–protein (RNP) complexes may expand the fields of
molecular robotics, nanomedicine, and synthetic biology. However, constructing and directly …