The 'ForensOMICS'approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

A Bonicelli, HL Mickleburgh, A Chighine, E Locci… - Elife, 2022 - elifesciences.org
The combined use of multiple omics allows to study complex interrelated biological
processes in their entirety. We applied a combination of metabolomics, lipidomics and …

[HTML][HTML] The application of metabolomics in forensic science with focus on forensic toxicology and time-of-death estimation

J Dawidowska, M Krzyżanowska, MJ Markuszewski… - Metabolites, 2021 - mdpi.com
Recently, the diagnostic methods used by scientists in forensic examinations have
enormously expanded. Metabolomics provides an important contribution to analytical …

[HTML][HTML] Post-mortem interval and microbiome analysis through 16S rRNA analysis: a systematic review

P Tozzo, I Amico, A Delicati, F Toselli, L Caenazzo - Diagnostics, 2022 - mdpi.com
The determination of the Post-Mortem Interval (PMI) is an issue that has always represented
a challenge in the field of forensic science. Different innovative approaches, compared to the …

A novel method for determining postmortem interval based on the metabolomics of multiple organs combined with ensemble learning techniques

X Lu, J Li, X Wei, N Li, L Dang, G An, Q Du… - International Journal of …, 2023 - Springer
Determining postmortem interval (PMI) is one of the most challenging and essential
endeavors in forensic science. Developments in PMI estimation can take advantage of …

[HTML][HTML] Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach

S Gandhi, V Chinnadurai, K Bhadra, I Gupta… - Scientific Reports, 2022 - nature.com
The main physiological challenge in high altitude environment is hypoxia which affects the
aerobic metabolism reducing the energy supply. These changes may further progress …

[HTML][HTML] Metabolomics investigation of post-mortem human pericardial fluid

A Chighine, M Stocchero, G Ferino… - International Journal of …, 2023 - Springer
Introduction Due to its peculiar anatomy and physiology, the pericardial fluid is a biological
matrix of particular interest in the forensic field. Despite this, the available literature has …

Looking for post-mortem metabolomic standardization: waiting for godot—the importance of post-mortem interval in forensic metabolomics

A Chighine, E Locci, M Nioi… - Chemical Research in …, 2021 - ACS Publications
Looking for Post-Mortem Metabolomic Standardization: Waiting for Godot—The Importance of
Post-Mortem Interval in Forensic Metabolomics | Chemical Research in Toxicology ACS ACS …

[HTML][HTML] Metabolomic studies for the evaluation of toxicity induced by environmental toxicants on model organisms

HM Kim, JS Kang - Metabolites, 2021 - mdpi.com
Environmental pollution causes significant toxicity to ecosystems. Thus, acquiring a deeper
understanding of the concentration of environmental pollutants in ecosystems and, clarifying …

High-resolution mass spectrometry: Theoretical and technological aspects

E Zarrouk, M Lenski, C Bruno, V Thibert… - … Analytique et Clinique, 2022 - Elsevier
Over the past decade, time-of-flight (TOF) and Orbitrap™(Thermo Fisher Scientific) mass
spectrometers have aroused a growing interest, and we observed a progressive …

[HTML][HTML] Postmortem ocular findings in the optical coherence tomography era: A proof of concept study based on six forensic cases

M Nioi, PE Napoli, R Demontis, E Locci, M Fossarello… - Diagnostics, 2021 - mdpi.com
Postmortem analysis of the ocular globe is an important topic for forensic pathology and
transplantology. Although crucial elements may be gathered from examining cadaveric …