Wound healing is a complicated process, and the effective management of wounds is a
major challenge. Natural herbal remedies have now become fundamental for the …

Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological
systems by hydrolysis of crocin as a bioactive metabolite. It is known to exist in several …

Inflammation is an essential pillar of the immune defense. On the other hand, chronic
inflammation is considered a hallmark of cancer initiation and progression. Chronic …

Glioblastoma (GBM) is known to be the most common and lethal primary malignant brain
tumor. Therapies against this neoplasia have a high percentage of failure, associated with …

Saffron, comprising of dried stigmas of the plant known as Crocus sativus, is one of the most
important and scantly cultivated agricultural products. It has been used as a precious spice …

Natural products with high pharmacological potential and low toxicity have been considered
as the novel therapeutic agents. Crocetin is an active constituent of saffron (Crocus sativus …

Cancer is a leading cause of death around the world. Apoptosis, one of the pathways of
programmed cell death, is a promising target for cancer therapy. Traditional Tibetan …

Aim To assess the potential role of saffron in downregulating inflammation and cytokine
storm during COVID-19. Main findings Three main compounds of saffron, ie, crocetin esters …

Combining natural antioxidants with synthetic anticancer agents is a helpful approach in
chemotherapy to reduce side effects and enhance the effectiveness of drugs. Saffron extract …

Background and Objectives: Cyclooxygenase-2 (COX-2) is mostly linked to inflammation
and has been validated as a molecular target for treating inflammatory diseases. The …