On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram

VR Cota, SAV Cançado, MFD Moraes - Frontiers in Neuroinformatics, 2023 - frontiersin.org
Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

[HTML][HTML] Epilepsy as a dynamical system, a most needed paradigm shift in epileptology

MFD Moraes, D de Castro Medeiros, FAG Mourao… - Epilepsy & Behavior, 2021 - Elsevier
The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …

Amygdala low-frequency stimulation reduces pathological phase-amplitude coupling in the pilocarpine model of epilepsy

I Mihály, K Orbán-Kis, Z Gáll, ÁJ Berki, RB Bod… - Brain Sciences, 2020 - mdpi.com
Temporal-lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and
warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was …

Persistence of neural function in animals submitted to seizure-suppressing scale-free nonperiodic electrical stimulation applied to the amygdala

LA Réboli, RM Maciel, JC de Oliveira… - Behavioural Brain …, 2022 - Elsevier
Based on the rationale that neural hypersynchronization underlies epileptic phenomena,
nonperiodic stimulation (NPS) was designed and successfully tested as an electrical …

[HTML][HTML] Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights

VR Cota, JC de Oliveira, LCM Damázio… - Epilepsy & Behavior, 2021 - Elsevier
Electrical stimulation of the central nervous system is a promising alternative for the
treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is …

Seizure suppression by asynchronous non-periodic electrical stimulation of the amygdala is partially mediated by indirect desynchronization from nucleus accumbens

JC De Oliveira, BMB Drabowski, S Rodrigues… - Epilepsy Research, 2019 - Elsevier
Electrical stimulation (ES) of the nervous system is a promising alternative for the treatment
of refractory epilepsy. Based on the understanding that seizures are the expression of neural …

Data-driven network dynamical model of rat brains during acute ictogenesis

VH Batista Tsukahara, JN de Oliveira Júnior… - Frontiers in neural …, 2022 - frontiersin.org
Epilepsy is one of the most common neurological disorders worldwide. Recent findings
suggest that the brain is a complex system composed of a network of neurons, and seizure …

In silico Investigation of the Effects of Distinct Temporal Patterns of Electrical Stimulation to the Amygdala Using a Network of Izhikevich Neurons

JPS Oliveira, VRP Discacciati, DC Medeiros… - … American Workshop on …, 2021 - Springer
Computational modeling is a powerful tool to investigate the mechanisms of neural function.
This work model in silico the effect of experimental electrical stimulation on a neuronal …

Implementation of Intra and Extracellular Nonperiodic Scale-Free Stimulation in silico for the NEURON Simulator

HCB Terra, FS Borges, MFD Moraes… - Latin American Workshop …, 2021 - Springer
Electrical stimulation of the brain is a largely used alternative for the treatment of myriad
neurological disorders. Although recognizably efficacious and safe, many details of the …

Electrographic spectral signatures of animals submitted to pentylenetetrazole-induced seizures and treated with bilateral asynchronous non-periodic stimulation

W de Souza Silva, RM Maciel, VR Cota - Latin American Workshop on …, 2019 - Springer
Non-periodic stimulation (NPS) has been shown to be an alternative to the treatment of
epilepsy due to its anticonvulsant power. In this work, we analyzed the effects of NPS in the …