Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …

Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features,
including antigen specificity, clonal expansion and memory. As such, NK cells share many …

Natural killer (NK) cells are present in the circulation and can also be found residing in
tissues, and these populations exhibit distinct developmental requirements and are thought …

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are populations of non-T,
non-B lymphocytes in peripheral tissues. Although NK and ILC1 subsets have been …

Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) cells and
tissue-resident ILC1s are critical for host defense against pathogens and tumors. Despite a …

Innate lymphoid cells (ILC) are a heterogeneous group of immune cells characterized by
lymphoid morphology and cytokine profile similar to T cells but which do not express clonally …

To optimize immunity to pathogens, B lymphocytes generate plasma cells with functionally
diverse antibody isotypes. By lineage tracing single cells within differentiating B cell clones …

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a
previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to …