The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Hypertension (HTN) and chronic kidney disease (CKD) are increasingly recognized in
pediatric patients and represent risk factors for cardiovascular morbidity and mortality later in …

ABSTRACT CORRÊA, HL, RVP NEVES, LA DEUS, MK SOUZA, AS HARO, F. COSTA, VL
SILVA, CAR SANTOS, MR MORAES, HG SIMÕES, JW NAVALTA, J. PRESTES, and TS …

Highlights•SGLT2i and their clinical applications in cardio-renal complications.•SGLT2i and
Acute kidney injury: fact or fright.•Possible underlying mechanisms of SGLT2i in cardio-renal …

The nexus of chronic kidney disease (CKD) and cardiovascular disease (CVD) amplifies the
morbidity and mortality of CKD, emphasizing the need for defining and establishing …

Oxidative stress occurs when there is an imbalance between reactive oxygen
species/reactive nitrogen species and antioxidant systems. The interplay between these …

Klotho, a multifunctional protein, acts as a co-receptor in fibroblast growth factor 23 and
exerts its impact through various molecular pathways, including Wnt, hypoxia-inducible …

As the limits of fetal viability have increased over the past 30 years, there has been a
growing body of evidence supporting the idea that chronic disease should be taken into …

Intrauterine development is crucial for life-long health; therefore, elucidation of its key
regulators is of interest for their potential prognostic and therapeutic implications. Originally …

A congenital or programmed reduction in glomerular number increases the susceptibility to
hypertension and kidney injury in adulthood thus, premature birth or low birth weight …