Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …

Increased effectiveness of pharmacological treatments in early RA has led many to believe
that difficult-to-treat, established RA is a condition of the past. However, there are still plenty …

Objective To compare the efficacy and safety of subcutaneous (SC) versus oral
administration of methotrexate (MTX) in patients with active rheumatoid arthritis (RA) …

Methotrexate (MTX) is a derivative of folic acid (folate) and commonly used as an anchor
drug for the treatment of rheumatoid arthritis (RA). The pharmacokinetics (PK) and …

Objective To develop a clinical pharmacogenetic model to predict the efficacy of
methotrexate (MTX) in rheumatoid arthritis (RA). Methods Two hundred five patients with …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by joint
destruction and severe morbidity. Methotrexate (MTX) is the standard first-line therapy of RA …

Methotrexate (MTX) is the anchor disease-modifying antirheumatic drug (DMARD) in
rheumatoid arthritis (RA) treatment. It is used in monotherapy and/or in combination with …

In this review, we especially cover the following themes: new clinical studies on the use of
MTX in RA, the use of MTX in other rheumatic conditions, prediction of response to MTX …

Methotrexate is a folate analog that is used in the treatment of cancers (eg acute
lymphoblastic leukemia, non-Hodgkin lymphoma, osteosarcoma, and colon cancer) and …

OBJECTIVE: Research has examined the association of folate-dependent gene
polymorphisms with methotrexate (MTX) toxicity in racially homogenous patients with …